Understanding Cancer-Related Tests: Electrolyte Levels

The essential electrolytes listed below are responsible for the critical job of keeping the body’s fluid in balance. Cancer, cancer treatments, and medications used to treat side effects can cause changes in electrolyte levels, which can potentially become dangerous if they become severe and untreated.  

Electrolyte level tests are part of the Basic Metabolic Panel and Complete Metabolic Panel. However, these tests can also be ordered independently by your physician. 

 Sodium (Na)  

  • Sodium is naturally found in some foods or added in the form of table salt. It helps maintain fluid outside of the cells in the body.  

  • Low levels of sodium – called hyponatremia - typically mean that there is extra fluid in the body. This can occur from:  

    • Excess water intake, kidney disease causing low water excretion, and/or elevated levels of hormones that regulate water  

  • Elevated levels of sodium in the blood – called hypernatremia – means that there is low water, or that water has been lost. The following can result in hypernatremia:   

    • Dehydration, sweat, vomiting, diarrhea, diabetes, low water intake, intense exercise, seizures, and high salt intake – eating / drinking salt or with saline solutions delivered through an IV  

  • Signs and symptoms of abnormal results include:  

Hyponatremia (low sodium)  

Hypernatremia (high sodium)  

Symptoms of mild hyponatremia:  

-Nausea   

-Malaise  

Symptoms of severe hyponatremia:  

-Headache  

-Lethargy  

-Obtundation   

-Seizures  

-Coma  

-Respiratory arrest  

It is important that low levels of sodium are replaced at an appropriate rate. Complications can occur if sodium is replaced too quickly, including seizures, severe fatigue (also called lethargy), or coma.  

Symptoms of mild hypernatremia:   

-Lethargy  

-Weakness  

-Irritability  

Symptoms of severe hypernatremia:  

-Twitching  

-Seizures  

-Coma  

  

Potassium (K) 

  • Potassium is found naturally in many foods (e.g., bananas, cantaloupe, apricots, etc.). It helps maintain fluid inside of the cells in the body.  

  • High potassium – hyperkalemia - may represent problems with the kidneys.  

  • Low potassium can be caused by low intake of foods with potassium, medications, sweat, loss of potassium from the GI tract (vomiting, diarrhea).  

  • Signs and symptoms of abnormal results include:  

Hyperkalemia (high potassium)  

Hypokalemia (low potassium)  

-Muscle weakness   

-Paralysis  

-Changes in heart rhythm – or arrhythmia – and electrocardiogram (EKG) changes  

-Muscle weakness   

-Paralysis  

-Arrhythmias and EKG changes  

-Issues tolerating glucose  

 Carbon Dioxide (CO2) 

  • Carbon dioxide is a colorless and odorless gas that is expelled by your body when you exhale. Most of the CO2 in your body is in the form of bicarbonate. This electrolyte helps control fluid and pH balance in your body.  

  • Abnormal results can indicate that your body is having trouble maintaining pH balance (acid-base balance). This can be the result of your lungs and/or kidneys having trouble removing the CO2 from your blood.  

  • Signs and symptoms of abnormal results include:  

High CO2  

Low CO2  

 -Shortness of breath  

-Headaches  

-Confusion  

-Hand Tremors  

-Seizures  

-Nausea  

-Fatigue  

-Nausea  

-Vomiting  

-Diarrhea  

  

 Chloride (Cl) 

  • Chloride is a type of electrolyte that helps your body control fluids levels and pH balance.  

  • Abnormal results in your body can indicate trouble with your kidneys, lungs, and/or heart.  

  • Abnormal levels do not always indicate that treatment is necessary. Drinking too much water or intake of too many OTC antacids can affect these results.  

  • Signs and symptoms of abnormal results include:  

Low Cl  

High Cl  

-Dehydration  

-Fatigue  

-Difficulty breathing  

-Vomiting  

-Diarrhea  

-Fatigue  

-Weakness  

-Increased thirst  

-Elevated blood pressure  

-Dry mucous membranes  

 Calcium (Ca) 

  • Calcium is an important electrolyte necessary in the proper functioning of your muscles and nerves.   

  • Calcium can be found in many foods we eat (I.e., milk, cheese, green leafy vegetables, soy)  

  • Abnormal results in your body can indicate trouble with your bones, kidney, and certain endocrine glands.  

  • Signs and symptoms of abnormal results include:  

Low Ca  

High Ca  

-Tingling in your lips, hands, feet  

-Muscle cramps  

-Arrhythmia  

-Spasms  

 -Nausea/Vomiting  

-Constipation  

-Confusion  

-Excessive thirst  

-Frequent urination  

-Bone/muscle pain  

 Glucose 

  • Glucose is a simple sugar that provides the energy source for our bodies to function.  

  • Abnormal results in your body can indicate signs of diabetes, liver disease, or trouble with the pancreas or adrenal glands.  

  • Signs and symptoms of abnormal results include:  

Low Glucose  

High Glucose  

-Feeling jittery  

-Nausea  

-Confusion  

-Fatigue  

-Hunger  

-Headaches  

-Increased urination  

-Excessive thirst  

-Fatigue  

-Vision changes  

-Weight loss  

-Neuropathy  

-Trouble with wound healing  

When to Contact Your Doctor, Health Care Provider, or Iris Oncology Nurse 

  • You are experiencing fever (temperature ≥100.4)  

  • You have unusual bleeding, bruising, or red spots under your skin  

  • You are experiencing dizziness or shortness of breath  

  • You have concerns about any symptoms that you are experiencing  

 

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Mayo Clinic Staff. (2020, February 21). Liver disease. Mayo Clinic. Retrieved January 19, 2022.

OncoLink Team. (2020). Comprehensive metabolic panel. OncoLink. Retrieved January 19, 2022.

Yin, L. K., & Tong, K. S. (2009, August 31). Elevated alt and AST in an asymptomatic person: What the primary care doctor should do? Malaysian family physician: the official journal of the Academy of Family Physicians of Malaysia. Retrieved January 19, 2022.